Conference News: Social Policy in Mineral-Rich Countries

This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide. Special emphasis is placed on labor rights, working conditions, labor market changes, and union organizing.UNRISD_SocialPolicyInMineralRichCountries.pdf: 189 downloads, before Oct. 1, 2020

Star Formation in the Field and Clusters of NGC 5253

We investigate the star formation history of both the bright star clusters and the diffuse `field star' population in the dwarf starburst galaxy NGC 5253 using STIS longslit ultraviolet spectroscopy. Our slit covers a physical area of 370 x 1.6 pc and includes 8 apparent clusters and several inter-cluster regions of diffuse light which we take to be the field. The diffuse light spectrum lacks the strong O-star wind features which are clearly visible in spectra of the brightest clusters. This discrepancy provides compelling evidence that the diffuse light is not reflected light from nearby clusters, but originates in a UV-bright field star population, and it raises the issue of whether the star formation process may be operating differently in the field than in clusters. We compare our spectra to STARBURST99 evolutionary synthesis models which incorporate a new low metallicity atlas of O-star spectra. We favor a scenario which accounts for the paucity of O-stars in the field without requiring the field to have a different IMF than the clusters: stellar clusters form continuously and then dissolve on ~10 Myr timescales and disperse their remaining stars into the field. We consider the probable contribution of an O-star deficient field population to the spatially unresolved spectra of high redshift galaxies. (Abridged)Comment: 26 pages, 10 figures, accepted for publication in Ap

Rancho Santa Fe Foundation (RSFF) Plan-to-Plan Report

Over the past two months, a USD project team conducted extensive research to inform the strategic planning process of the Rancho Santa Fe Foundation (RSFF). The team identified three key questions that will be important for the RSFF to address as it positions itself for growth. Those questions are: 1) What is the identity of the RSFF, both internally and externally; 2) How should the RSFF define community; and 3) How should the RSFF define growth?https://digital.sandiego.edu/npi-bpl-strategicplanning/1000/thumbnail.jp

RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways

Glucocorticoids are steroids that reduce inflammation and are used as immunosuppressive drugs for many diseases. They are also the mainstay for the treatment of minimal change nephropathy (MCN), which is characterised by an absence of inflammation. Their mechanisms of action remain elusive. Evidence suggests that immunomodulatory drugs can directly act on glomerular epithelial cells or ‘podocytes’, the cell type which is the main target of injury in MCN. To understand the nature of glucocorticoid effects on non-immune cell functions, we generated RNA sequencing data from human podocyte cell lines and identified the genes that are significantly regulated in dexamethasone-treated podocytes compared to vehicle-treated cells. The upregulated genes are of functional relevance to cytoskeleton-related processes, whereas the downregulated genes mostly encode pro-inflammatory cytokines and growth factors. We observed a tendency for dexamethasone-upregulated genes to be downregulated in MCN patients. Integrative analysis revealed gene networks composed of critical signaling pathways that are likely targeted by dexamethasone in podocytes

An evaluation of an online student portfolio for the development of engineering graduate attributes

An online student portfolio was evaluated as a means for engaging students with the concept of graduate attributes, and for documenting student attainment of graduate attributes. Students rated the portfolio system as easy to use, and indicated that it helped them to appreciate the skills and knowledge they had developedNo Full Tex

Primordial nucleosynthesis with a varying fine structure constant: An improved estimate

We compute primordial light-element abundances for cases with fine structure constant alpha different from the present value, including many sources of alpha dependence neglected in previous calculations. Specifically, we consider contributions arising from Coulomb barrier penetration, photon coupling to nuclear currents, and the electromagnetic components of nuclear masses. We find the primordial abundances to depend more weakly on alpha than previously estimated, by up to a factor of 2 in the case of ^7Li. We discuss the constraints on variations in alpha from the individual abundance measurements and the uncertainties affecting these constraints. While the present best measurements of primordial D/H, ^4He/H, and ^7Li/H may be reconciled pairwise by adjusting alpha and the universal baryon density, no value of alpha allows all three to be accommodated simultaneously without consideration of systematic error. The combination of measured abundances with observations of acoustic peaks in the cosmic microwave background favors no change in alpha within the uncertainties.Comment: Phys. Rev. D accepted version; minor changes in response to refere

Review of two-photon exchange in electron scattering

We review the role of two-photon exchange (TPE) in electron-hadron scattering, focusing in particular on hadronic frameworks suitable for describing the low and moderate Q^2 region relevant to most experimental studies. We discuss the effects of TPE on the extraction of nucleon form factors and their role in the resolution of the proton electric to magnetic form factor ratio puzzle. The implications of TPE on various other observables, including neutron form factors, electroproduction of resonances and pions, and nuclear form factors, are summarized. Measurements seeking to directly identify TPE effects, such as through the angular dependence of polarization measurements, nonlinear epsilon contributions to the cross sections, and via e+ p to e- p cross section ratios, are also outlined. In the weak sector, we describe the role of TPE and gamma-Z interference in parity-violating electron scattering, and assess their impact on the extraction of the strange form factors of the nucleon and the weak charge of the proton.Comment: 73 pages, 40 figures, review article for Prog. Part. Nucl. Phys. (dedicated to the memory of John A. Tjon

Bump2Baby and Me:protocol for a randomised trial of mHealth coaching for healthy gestational weight gain and improved postnatal outcomes in high-risk women and their children

BACKGROUND: Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both maternal and child risk of developing non-communicable diseases such as type 2 diabetes and obesity. Whilst lifestyle interventions in pregnancy and postpartum reduce this risk, a research translation gap remains around delivering implementable interventions with adequate population penetration and participation. Impact Diabetes Bump2Baby is an implementation project of an evidence-based system of care for the prevention of overweight and obesity. Bump2Baby and Me is the multicentre randomised controlled trial investigating the effectiveness of a mHealth coaching programme in pregnancy and postpartum for women at high risk of developing GDM. METHODS: Eight hundred women will be recruited in early pregnancy from 4 clinical sites within Ireland, the UK, Spain, and Australia. Women will be screened for eligibility using the validated Monash GDM screening tool. Participants will be enrolled from 12 to 24 weeks’ gestation and randomised on a 1:1 basis into the intervention or control arm. Alongside usual care, the intervention involves mHealth coaching via a smartphone application, which uses a combination of synchronous and asynchronous video and text messaging, and allows for personalised support and goal setting with a trained health coach. The control arm receives usual care. All women and their children will be followed from early pregnancy until 12 months postpartum. The primary outcome will be a difference in maternal body mass index (BMI) of 0.8 kg/m(2) at 12 months postpartum. Secondary maternal and infant outcomes include the development of GDM, gestational weight gain, pregnancy outcomes, improvements in diet, physical activity, sleep, and neonatal weight and infant growth patterns. The 5-year project is funded by the EU Commission Horizon 2020 and the Australian National Health and Medical Research Council. Ethical approval has been received. DISCUSSION: Previous interventions have not moved beyond tightly controlled efficacy trials into routine service delivery. This project aims to provide evidence-based, sustainable support that could be incorporated into usual care for women during pregnancy and postpartum. This study will contribute evidence to inform the early prevention of non-communicable diseases like obesity and diabetes in mothers and the next generation. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12620001240932. Registered on 19 November 2020 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13063-021-05892-4

Fine-root production in small experimental gaps in successional mixed boreal forests

The effects of small 10 m x 10 m experimental above-ground gaps on fine-root production for the first two years were studied in three fire-initiated stands of the northwestern mixed broad-leaf-conifer boreal forest of Quebec. The 48-yr-old forest is dominated by Populus tremuloides (Trembling aspen), the 122-yr-old forest by a mixture of P. tremuloides, Abies balsamea (balsam fir) and Picea glauca (white spruce), and the 232-yr-old forest by Thuja occidentalis (eastern white cedar) and A. balsamea, with some P. tremuloides. 40 root-ingrowth bags were installed in different locations in and around each gap (at gap center, 1 to 2 m either side of gap edge and in adjacent control plots). Half of the ingrowth bags were harvested after one year following gap creation, the other half after two years. Roots were sorted into different species grouping. Fine-root production was statistically (P < 0.05) larger in the youngest forest compared to the two older ones after one year, but not after two years. The individual species or groups of species increased, decreased or showed no change in fine-root production in gaps, but overall we did not observe a major shift in species proportion between gap and control plots after two years. Some herbs and also Taxus canadensis seemed to benefit in terms of fine-root growth from such small openings after two years. No statistical differences (P > 0.10) in total fine-root production were found among locations within and outside gaps in either year. However, there was a clear tendency for fine-root production to be smaller in gap center than in the other locations for the two younger successional forests the first year after gap creation. We conclude that small above-ground gaps (i.e. < 100 m2) do not produce a significant and long-lasting below-ground gap in terms of total fine-root production in the successional forests investigated

Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women

Physical activity is a known modifiable lifestyle means for reducing postmenopausal breast cancer risk, but the biologic mechanisms are not well understood. Metabolic factors may be involved. In this study, we aimed to determine the effects of exercise on insulin resistance (IR) indicators, IGF1, and adipokines in postmenopausal women. The Alberta Physical Activity and Breast Cancer Prevention Trial was a two-armed randomized controlled trial in postmenopausal, inactive, cancer-free women. A year-long aerobic exercise intervention of 225 min/week (n=160) was compared with a control group asked to maintain usual activity levels (n=160). Baseline, 6- and 12-month serum levels of insulin, glucose, IGF1, IGF-binding protein 3 (IGFBP3), adiponectin, and leptin were assayed, and after data collection, homeostasis model assessment of IR (HOMA-IR) scores were calculated. Intention-to-treat analyses were performed using linear mixed models. The treatment effect ratio (TER) of exercisers to controls was calculated. Data were available on 308 (96.3%) women at 6 months and 310 (96.9%) women at 12 months. Across the study period, statistically significant reductions in insulin (TER=0.87, 95% confidence interval (95% CI)=0.81–0.93), HOMA-IR (TER=0.86, 95% CI=0.80–0.93), and leptin (TER=0.82, 95% CI=0.78–0.87), and an increase in the adiponectin/leptin ratio (TER=1.21, 95% CI=1.13–1.28) were observed in the exercise group compared with the control group. No significant differences were observed for glucose, IGF1, IGFBP3, adiponectin or the IGF1/IGFBP3 ratio. Previously inactive postmenopausal women who engaged in a moderate-to-vigorous intensity exercise program experienced changes in insulin, HOMA-IR, leptin, and adiponectin/leptin that might decrease the risk for postmenopausal breast cancer